Test Code: FVL Preferred Name Factor V Leiden gene testing

24 hours
7 days
Medicare Item with conditions - see General notes
7 days

Test Tubes

ImageSpecimen TypeSpecimen VolumeTube Type
Blood (adult)3 mLEDTA 3 mL whole blood (Lavender top)
Blood (paediatric)250 µLEDTA 500 uL Microtainer (Lavender Top)


Not to be confused with Factor V assay.


A medicare rebate is available for this test if the patient meets the following criteria:

- Patient has a personal history of a proven venous thrombosis or pulmonary embolism


- Patient has a first degree relative who has been proven to have a mutation.

If the patient does not meet either criteria then the test will be billed at $60 non-MBS to patient.

APPLICATION:  This test is performed by a PCR technique that detects the Prothrombin G20210A mutation and Factor V G1691A mutation simultaneously.

INTERPRETATION:  The Factor V G1691A variation is responsible for the activated protein C resistance phenotype detected by functional assays.  When compared to the wild type activated factor V protein, this mutation leads to an increased resistance / slower cleavage rate of the activated factor V Leiden by the anticoagulant activated protein C.  In Caucasians this common molecular polymorphism may be the predisposing risk factor in as many as 20% of venous thrombotic events, and in carriers may increase their risk of venous thrombosis by seven fold.

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