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Test Code: JAK2 Preferred Name JAK2 PCR

No
1 day
Weekly
Weekly
Medicare Item
N/A

Test Tubes

ImageSpecimen TypeSpecimen VolumeTube Type
Peripheral blood (Adult)5-10ml2x EDTA 3 mL whole blood (Lavender top)
Peripheral blood (Paediatric)1-2ml2x EDTA 2mL Paediatric ( Lavender Top)
Bone Marrow1mlEDTA 3 mL whole blood (Lavender top)

COLLECTION NOTES

--No collection notes--

GENERAL NOTES



Two recent independent studies have determined that a V617F mutation of the JAK2 gene is present in many patients afflicted with MPDs (Baxter, E.J., et. al., Lancet 2005: 365: 1054-61) (Levine, et. al., Cancer Cell     2005: 7(4): 387-97).   These studies demonstrated that a majority of patients with polycythemia vera, and a significant number of patients  (up to 50%) with essential thrombocythemia and myeloid metaplasia with myelofibrosis have a clonal acquired somatic V617F JAK2 activating mutation.

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