1. Raised antibody levels to the yeast Saccharomyces cerevisiae have been shown to be associated with inflammatory processes of the intestine. 2. A positive Anti-saccharomyces cerevisiae (ASCA) test is suggestive of, but not diagnostic for Crohn's disease. 3. Positive results can occur in normal patients and in other diseases (i.e. Coeliac Disease) 4. The assay has not been validated for paediatric patients. 5. ASCA may be used in combination with Peripheral Anti-Neutrophil Cytoplasmic Antibody (pANCA) to increase the specificity where a positive ASCA and negative pANCA favours Crohn's Disease.