Test Code: HLYTIC Preferred Name Haemolytic screen

1 hour
24 hours
Medicare Item
72 hours

Test Tubes

ImageSpecimen TypeSpecimen VolumeTube Type
Blood (adult) and3 mLEDTA 3 mL whole blood (Lavender top)
Blood8 mLSST with gel 8.5 mL (Dark Yellow Top)
Blood (paediatric)1 mLEDTA 2 mL Paediatric ( Lavender Top)


Haematology performs FBC/Reticulocytes.
Blood Bank performs a DAT.
Biochemistry performs Haptoglobins and LD.


FBC + RETIC - 65070
DAT - 65114
HAPT - 66632
LD - 66500

A normocytic anaemia with reticulocytosis and unconjugated bilirubinaemia would raise the suspicion of a haemolytic process. Examination of the peripheral blood smear may reveal many clues as to the cause of haemolysis, and feedback from a scientist/haematologist is invaluable in this regard. Haptoglobin is an acute phase protein and may be "normal" in certain cases of extravascular haemolytic anaemias. Haptoglobin is typically undetectable in intravascular haemolysis; LD can be expected to be > 1000 in intravascular haemolysis but normally not as high in extravascular haemolysis. If the DAT is negative, the next test suggested is urine-haemosiderin, which will be positive in chronic intravascular haemolysis. PNH is one of the causes of chronic intravascular haemolysis and the diagnosis can now be confirmed flow cytometrically

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