Test Code: PTH202 Preferred Name Prothrombin gene mutation (G20210A)

24 hours
Medicare Item with conditions - see General notes
7 days

Test Tubes

ImageSpecimen TypeSpecimen VolumeTube Type
Blood3 mLEDTA 3 mL whole blood (Lavender top)



A Medicare rebate is available for this test if the patient meets the following criteria: - Patient has a personal history of a proven venous thrombosis or pulmonary embolism OR - Patient has a first degree relative who has been proven to have a mutation. If the patient does not meet either criteria then the test will be billed at $60 non-MBS to patient.

This test is performed by a PCR technique that detects the Prothrombin G20210A mutation and Factor V G1691A mutation simultaneously.

The prothrombin G20210A variation, may act through an unexplained increase in plasma prothrombin levels.  The prevalence of the mutated allele in the study by Poort et al.  Blood was 6.3% among venous thrombosis cases, and 2.3% in controls, indicating a carrier odds ratio for thrombosis of 2.8.

Back to top