Sodium Citrate 1.8 mL Paed (Clear/Pale Blue Inner)
Blood (neonate)
1.0ml
Sodium Citrate 1.0 mL Neonate (Pale Blue Top)
COLLECTION NOTES
Accurate filling of specimen tube essential. All collections that include Coagulation testing must be sent to the laboratory in a BLUE specimen bag. Please ask the patient what anticoagulants they are on and the dose, record on request form.
GENERAL NOTES
The ECHIS test is used to differentiate liver disease from Vit K deficiency/Vit K antagonism as a possible cause of a prolonged PT. Both active and inactive Vit K-dependent factors are decreased in liver disease, resulting in a prolonged PT AND prolonged ECHIS time. Vit K deficiency/antagonism results in a reduced ACTIVE form but the INACTIVE form is normal or increased; PT is prolonged but ECHIS time is normal. [ECHIS venom activates both the functionally inactive and the carboxylated active F II (prothrombin) to thrombin.]