Test Code: GliadA Preferred Name Gliadin antibodies
Once per w
|Image||Specimen Type||Specimen Volume||Tube Type|
||Blood (adult)||5 mL||SST with gel 8.5 mL (Dark Yellow Top)
||Blood (paediatric)||1 mL||2x SST with gel 600 uL Paed (Red or Yellow top)
Requests for 'Coeliac Screening' will be tested for anti-tissue transglutaminase antibodies.
APPLICATION: Gliadin antibodies are of limited application in diagnosis of coeliac disease and dermatitis herpetiformis and are used for follow up of dietary restriction and challenge.
Tissue transglutaminase antibodies (Endomysial antibodies) are more specific for the diagnosis of coeliac disease. If the patient is IgA deficient then testing for IgG Gliadin is indicated.
INTERPRETATION: A positive result for either IgG or IgA antibodies to gliadin is found in up to 10% of the normal population.
The diagnosis of coeliac disease should not be made on the basis of these antibodies alone.
A positive result for both IgG and IgA gliadin antibodies should be followed up by a small intestinal biopsy if clinical suspicion is high.
Positive IgG gliadin antibodies in the absence of IgA gliadin antibodies should raise the possiblity of coeliac disease associated with IgA deficiency.
REFERENCE: Wong R., et al. Pathology 2003; 35: 285-304