Requests for 'Coeliac Screening' will be tested for anti-tissue transglutaminase antibodies- IgG
APPLICATION: Gliadin antibodies are of limited application in diagnosis of coeliac disease and dermatitis herpetiformis and are used for follow up of dietary restriction and challenge.
Tissue transglutaminase antibodies (Endomysial antibodies) are more specific for the diagnosis of coeliac disease. INTERPRETATION: A positive result for either IgG antibodies to gliadin is found in up to 10% of the normal population.
The diagnosis of coeliac disease should not be made on the basis of these antibodies alone.
A positive result forIgG gliadin antibodies should be followed up by a small intestinal biopsy if clinical suspicion is high.
REFERENCE: Wong R., et al. Pathology 2003; 35: 285-304